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Junk DNA: A Journey Through the Dark Matter of the Genome

Junk DNA: A Journey Through the Dark Matter of the Genome
 

From the author of The Epigenetics Revolution ( A book that would have had Darwin swooning. --Guardian) comes a lucid and engaging report from the cutting edge of genomic biology.

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ISBN 9780231170857
Barcode 9780231170857
Published 15 May 2017 by Columbia University Press
Format Trade Paperback/Paperback
Alternate Format(s) View All (4 other possible title(s) available)
Language English (translated from: English)
Author(s) By Carey, Nessa
Availability Internationally sourced on backorder; allow 4-8 weeks

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Full details for this title

ISBN-13 9780231170857
ISBN-10 0231170858
Stock Available
Status Internationally sourced on backorder; allow 4-8 weeks
Publisher Columbia University Press
Imprint Columbia University Press
Publication Date 15 May 2017
International Publication Date 20 June 2017
Publication Country United States United States
Format Trade Paperback/Paperback
Language English
Translated from English
Author(s) By Carey, Nessa
Category Award Winning
Popular Science
Evolution
DNA
Cellular Biology
Biotechnology
Number of Pages 360
Dimensions Width: 152mm
Height: 229mm
Weight Not specified - defaults to 600g
Interest Age General Audience
Reading Age General Audience
Library of Congress Genomics, Human genome, Eukaryotic cells, Gene therapy, Recombinant DNA
NBS Text Popular Science
ONIX Text Professional and scholarly
Dewey Code 572.86
Catalogue Code Not specified

Description of this Book

For decades after the identification of the structure of DNA, scientists focused only on genes, the regions of the genome that contain codes for the production of proteins. Other regions that make up 98 percent of the human genome were dismissed as junk, sequences that serve no purpose. But researchers have recently discovered variations and modulations in this junk DNA that are involved with a number of intractable diseases. Our increasing knowledge of junk DNA has led to innovative research and treatment approaches that may finally ameliorate some of these conditions. Junk DNA can play vital and unanticipated roles in the control of gene expression, from fine-tuning individual genes to switching off entire chromosomes. These functions have forced scientists to revisit the very meaning of the word gene and have engendered a spirited scientific battle over whether or not this genomic nonsense is the source of human biological complexity. Drawing on her experience with leading scientific investigators in Europe and North America, Nessa Carey provides a clear and compelling introduction to junk DNA and its critical involvement in phenomena as diverse as genetic diseases, viral infections, sex determination in mammals, and evolution. We are only now unlocking the secrets of junk DNA, and Nessa Carey's book is an essential resource for navigating the history and controversies of this fast-growing, hotly disputed field.

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Awards, Reviews & Star Ratings

Awards Commended for One of The Independent's Best Science Books 2015
NZ Review Engaging, informative, and humorous, Nessa Carey's Junk DNA will be of interest to many readers. -- Sharon Y. R. Dent, University of Texas MD Anderson Cancer Center Carey makes two points very clearly: that our understanding is tentative and evolving, and that chromosomal functioning is far more intricate than anyone ever hypothesized. Publisher's Weekly Junk DNA provides a cutting-edge, exhaustive guide to the rapidly changing, ever-more mysterious genome. -- Linda Geddes New Scientist [Junk DNA], which is frequently humorous and well documented, does a fine job of explaining a complex subject for lay readers who are willing to put in some effort. Library Journal Carey's enthusiasm for her subject is infectious... An excellent introduction to a subject that we are certain to be hearing a lot more about in the near future. -- Mark Diston The Register Junk DNA serves as a nice primer. The Scientist The first popular overview of this field... [Carey] has an excellent grasp of the history of junk DNA and its implications for both basic and applied science. She has a gift for analogies and converts complex biochemistry into imagery that brings it to a level nonspecialists can grasp. -- Elof Axel Carlson The Quarterly Review of Biology

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Author's Bio

Nessa Carey is a visiting professor at Imperial College, London. She earned her Ph.D. in virology from the University of Edinburgh. Having worked in the biotech and pharmaceutical industries for more than a decade, she maintains strong relationships with leading researchers in Europe and across the United States, at such institutions as the Harvard Medical School, the University of Pennsylvania, the Wistar Institute, the MD Anderson Cancer Center, and the University of Southern California. Carey is also the author of The Epigenetics Revolution: How Modern Biology Is Rewriting Our Understanding of Genetics, Disease, and Inheritance.

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